Get Some Stability
Whether you use manual or automatic settings for taking photos in low light, it's crucial that you hold the camera steady. Low light camera settings mean the shutter will open wider and stay open longer. As a result, during each shot, you have to keep the camera as still as possible to get a noise-free, motion-free shot.
Many digital cameras include a stabilization feature that corrects for small movements. Our human biology causes our muscles to constantly correct, meaning we often have shaky hands even when we're trying to be as still as possible. Digital stabilization helps counteract those shaky hands. This stabilization is limited, though, and less effective in dim conditions.
For best results in stabilizing your photo, consider mounting your camera on a stable surface. You can't always rely on having a table or chair for that purpose, so consider a tripod or monopod. The tripod lets you set up a shot in advance, and it offers a consistent position for the camera when taking multiple photos. The monopod gives you the stable base you need during each shot along with the freedom to move or rotate between shots.
Our next tip goes back to the settings you'll want to consider when making manual adjustments for low-light shots.